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1996-02-27
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Document 0479
DOCN M9630479
TI The ontogeny of class-regulation of CD4+ T lymphocyte populations.
DT 9603
AU Carneiro J; Stewart J; Coutinho A; Coutinho G; Unite d'Immunobiologie,
Institut Pasteur, Paris, France.
SO Int Immunol. 1995 Aug;7(8):1265-77. Unique Identifier : AIDSLINE
MED/96022648
AB The differential class-regulation of CD4+ T lymphocyte populations is
believed to play a major role in determining the qualitative behaviour
of the immune system, and in the fate of immune responses in particular.
In this article we propose a model for the dynamics of the Th1 and Th2
subpopulations. We put forward the concept of an 'antigenic niche' which
allows us to postulate that the key feature underlying the regulation of
Th differentiation pathways is the population dynamics of the
lymphocytes themselves. Using this model we are able to account for a
number of well established experimental observations which were hitherto
apparently unrelated and poorly understood. This suggests that our
simplified model might be capturing some essential features of the
immune system.
DE Animal *Antigens, CD4 Cell Differentiation/IMMUNOLOGY Human
*Lymphocyte Transformation *Models, Immunological Support, Non-U.S.
Gov't *Th1 Cells/CLASSIFICATION/CYTOLOGY/IMMUNOLOGY *Th2
Cells/CLASSIFICATION/CYTOLOGY/IMMUNOLOGY JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).